public sealed class LayoutProjectItem : ArcGIS.Desktop.Internal.Core.ProjectItem, ArcGIS.Desktop.Core.IMetadata, ArcGIS.Desktop.Core.IProjectItem, System.ComponentModel.INotifyPropertyChanged  

{
  LayoutProjectItem layoutProjItem = Project.Current.GetItems<LayoutProjectItem>().FirstOrDefault(item => item.Name.Equals("myLayout"));
  // Use layoutProjItem;
}

{
  //Gets all the layouts in the current project
  IEnumerable<LayoutProjectItem> projectLayouts = Project.Current.GetItems<LayoutProjectItem>();
  foreach (var layoutItem in projectLayouts)
  {
    //Do Something with the layout
  }
}

{
  //GetItems searches project content
  var map = Project.Current.GetItems<MapProjectItem>().FirstOrDefault(m => m.Name == "Map1");
  var layout = Project.Current.GetItems<LayoutProjectItem>().FirstOrDefault(m => m.Name == "Layout1");
  var folders = Project.Current.GetItems<FolderConnectionProjectItem>();
  var style = Project.Current.GetItems<StyleProjectItem>().FirstOrDefault(s => s.Name == "ArcGIS 3D");

  //Find item uses a catalog path. The path can be to a file or dataset
  var fcPath = @"C:\Pro\CommunitySampleData\Interacting with Maps\Interacting with Maps.gdb\Crimes";
  var pdfPath = @"C:\Temp\Layout1.pdf";
  var imgPath = @"C:\Temp\AddinDesktop16.png";

  var fc = Project.Current.FindItem(fcPath);
  var pdf = Project.Current.FindItem(pdfPath);
  var img = Project.Current.FindItem(imgPath);
}

{
  LayoutProjectItem layoutItemByName = Project.Current.GetItems<LayoutProjectItem>()
    .FirstOrDefault((lpi) => lpi.Name == "MyLayout");
  //Note: Needs QueuedTask to run
  Layout layoutByName = layoutItemByName.GetLayout();
}

{
  //Reference layout project items and their associated layout.
  //A layout project item is an item that appears in the Layouts
  //folder in the Catalog pane.
  //Reference all the layout project items
  IEnumerable<LayoutProjectItem> layoutProjectItems =
                       Project.Current.GetItems<LayoutProjectItem>();

  //Or reference a specific layout project item by name
  LayoutProjectItem specificLayoutItem = Project.Current.GetItems<LayoutProjectItem>()
                             .FirstOrDefault(item => item.Name.Equals("MyLayoutItem"));
}

{
  //Open a layout project item in a new view.
  //A layout project item may exist but it may not be open in a view. 

  //Reference a layout project item by name
  LayoutProjectItem layoutItemByName = Project.Current.GetItems<LayoutProjectItem>()
                            .FirstOrDefault(item => item.Name.Equals("MyLayoutItem"));

  //Get the layout associated with the layout project item
  //Note: Needs QueuedTask to run
  Layout layoutFromItem = layoutItemByName.GetLayout();  //Worker thread

  //Create the new pane - call on UI
  ILayoutPane iNewLayoutPane = await ProApp.Panes.CreateLayoutPaneAsync(layout); //GUI thread
}