public static Task<ILayoutPane> CreateLayoutPaneAsync( 
   PaneCollection paneCollection,
   Layout layout
)

{
  //Open a layout project item in a new view.
  //A layout project item may exist but it may not be open in a view. 

  //Reference a layout project item by name
  LayoutProjectItem layoutItemByName = Project.Current.GetItems<LayoutProjectItem>()
                            .FirstOrDefault(item => item.Name.Equals("MyLayoutItem"));

  //Get the layout associated with the layout project item
  //Note: Needs QueuedTask to run
  Layout layoutFromItem = layoutItemByName.GetLayout();  //Worker thread

  //Create the new pane - call on UI
  ILayoutPane iNewLayoutPane = await ProApp.Panes.CreateLayoutPaneAsync(layout); //GUI thread
}

{
  //Create a new, basic layout and open it.
  //Create layout with minimum set of parameters on the worker thread
  //Note: Needs QueuedTask to run
  var myNewLayout = LayoutFactory.Instance.CreateLayout(8.5, 11, LinearUnit.Inches);
  myNewLayout.SetName("New 8.5x11 Layout");

  //Open new layout on the GUI thread
  await ProApp.Panes.CreateLayoutPaneAsync(myNewLayout);
}

{
  //Create a new layout using a modified CIM and open it.
  //The CIM exposes additional members that may not be
  //available through the managed API.  
  //In this example, optional guides are added.
  //Create a new CIMLayout on the worker thread

  //Note: Needs QueuedTask to run
  //Set up a CIM page
  CIMPage newPage = new CIMPage
  {
    //required parameters
    Width = 8.5,
    Height = 11,
    Units = LinearUnit.Inches,

    //optional rulers
    ShowRulers = true,
    SmallestRulerDivision = 0.5,

    //optional guides
    ShowGuides = true
  };
  CIMGuide guide1 = new CIMGuide
  {
    Position = 1,
    Orientation = Orientation.Vertical
  };
  CIMGuide guide2 = new CIMGuide
  {
    Position = 6.5,
    Orientation = Orientation.Vertical
  };
  CIMGuide guide3 = new CIMGuide
  {
    Position = 1,
    Orientation = Orientation.Horizontal
  };
  CIMGuide guide4 = new CIMGuide
  {
    Position = 10,
    Orientation = Orientation.Horizontal
  };

  List<CIMGuide> guideList = new List<CIMGuide>
  {
    guide1,
    guide2,
    guide3,
    guide4
  };
  newPage.Guides = guideList.ToArray();

  //Construct the new layout using the customized cim definitions
  var layout_local = LayoutFactory.Instance.CreateLayout(newPage);
  layout_local.SetName("New 8.5x11 Layout");

  //Open new layout on the GUI thread
  await ProApp.Panes.CreateLayoutPaneAsync(layout_local);

}