public void SetGuideColor( 
   CIMColor color
)

{
  //keep graphic element insert tool active
  ApplicationOptions.LayoutOptions.KeepLastToolActive = true;
  //no warning when deleting a map frame results in other elements being deleted
  ApplicationOptions.LayoutOptions.WarnAboutAssociatedSurrounds = false;
  //path to .pagx files used as templates
  ApplicationOptions.LayoutOptions.LayoutTemplatePath = @"D:\data\layout_templates";

  var guideColor = ApplicationOptions.LayoutOptions.GetGuideColor();
  // set guide color
  //Note: Must be on QueuedTask.Run
  ApplicationOptions.LayoutOptions.SetGuideColor(ColorFactory.Instance.RedRGB);
}